1bt8
From Proteopedia
(New page: 200px<br /> <applet load="1bt8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bt8, resolution 1.85Å" /> '''P.SHERMANII SOD(FE+...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BT8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BT8 OCA]]. | + | 1BT8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Structure known Active Sites: FEA and FEB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BT8 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Propionibacterium freudenreichii subsp. shermanii]] | [[Category: Propionibacterium freudenreichii subsp. shermanii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Superoxide dismutase]] | ||
[[Category: Schmidt, M.]] | [[Category: Schmidt, M.]] | ||
[[Category: FE]] | [[Category: FE]] | ||
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[[Category: superoxide dismutase]] | [[Category: superoxide dismutase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:23:39 2007'' |
Revision as of 12:18, 30 October 2007
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P.SHERMANII SOD(FE+3) PH 10.0
Overview
The structure of the Propionibacterium freudenreichii subspecies shermanii, superoxide dismutase (SOD) was determined at various pH values. As a, comparison, the structure of the fluoride coordinated SOD was solved. The, SOD crystallizes at pH 6.1 in the space group C2221 with two subunits, A, and B, in the asymmetric unit. An increase of the pH value changes the, cell parameters slightly but not the symmetry of the crystals. The overall, structure of the SOD remains a compact tetrameter and is comparable to, that at pH 6.1 no matter whether the pH increases or fluoride is added. At, values above pH 7.4, an additional hydroxide ion can bind to the active, center. Its position is similar to the binding site of the fluoride. The, coordination number changes from five to six if the pH ... [(full description)]
About this Structure
1BT8 is a [Single protein] structure of sequence from [Propionibacterium freudenreichii subsp. shermanii] with FE as [ligand]. Active as [Superoxide dismutase], with EC number [1.15.1.1]. Structure known Active Sites: FEA and FEB. Full crystallographic information is available from [OCA].
Reference
Manipulating the coordination mumber of the ferric iron within the cambialistic superoxide dismutase of Propionibacterium shermanii by changing the pH-value A crystallographic analysis., Schmidt M, Eur J Biochem. 1999 May;262(1):117-27. PMID:10231372
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