2bt1
From Proteopedia
(New page: 200px<br /> <applet load="2bt1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bt1, resolution 2.70Å" /> '''EPSTEIN BARR VIRUS ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BT1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 2BT1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]] with MG and DUP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BT1 OCA]]. |
==Reference== | ==Reference== | ||
The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases., Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP, Structure. 2005 Sep;13(9):1299-310. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16154087 16154087] | The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases., Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP, Structure. 2005 Sep;13(9):1299-310. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16154087 16154087] | ||
| - | [[Category: | + | [[Category: Human herpesvirus 4]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: dUTP diphosphatase]] | ||
[[Category: Buisson, M.]] | [[Category: Buisson, M.]] | ||
[[Category: Burmeister, W.P.]] | [[Category: Burmeister, W.P.]] | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:24:07 2007'' |
Revision as of 12:19, 30 October 2007
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EPSTEIN BARR VIRUS DUTPASE IN COMPLEX WITH A,B-IMINO DUTP
Overview
Deoxyuridine 5'-triphosphate pyrophosphatases (dUTPases) are ubiquitous, enzymes cleaving dUTP into dUMP and pyrophosphate. They occur as, monomeric, dimeric, or trimeric molecules. The trimeric and monomeric, enzymes both contain the same five characteristic sequence motifs but in a, different order, whereas the dimeric enzymes are not homologous. Monomeric, dUTPases only occur in herpesviruses, such as Epstein-Barr virus (EBV)., Here, we describe the crystal structures of EBV dUTPase in complex with, the product dUMP and a substrate analog alpha,beta-imino-dUTP. The, molecule consists of three domains forming one active site that has a, structure extremely similar to one of the three active sites of trimeric, dUTPases. The three domains functionally correspond to the subunits of the, ... [(full description)]
About this Structure
2BT1 is a [Single protein] structure of sequence from [Human herpesvirus 4] with MG and DUP as [ligands]. Active as [dUTP diphosphatase], with EC number [3.6.1.23]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases., Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP, Structure. 2005 Sep;13(9):1299-310. PMID:16154087
Page seeded by OCA on Tue Oct 30 14:24:07 2007
Categories: Human herpesvirus 4 | Single protein | DUTP diphosphatase | Buisson, M. | Burmeister, W.P. | Cusack, S. | SPINE, Structural.Proteomics.in.Europe. | Seigneurin, J.M. | Tarbouriech, N. | DUP | MG | Dutpase | Hydrolase | Monomer | Nucleotide metabolism | Spine | Structural genomics | Structural proteomics in europe
