9ant

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{{Seed}}
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==ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX==
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[[Image:9ant.png|left|200px]]
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<StructureSection load='9ant' size='340' side='right' caption='[[9ant]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ant]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ANT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=9ANT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=9ant FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ant OCA], [http://www.rcsb.org/pdb/explore.do?structureId=9ant RCSB], [http://www.ebi.ac.uk/pdbsum/9ant PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/9ant_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Homeodomains are one of the key families of eukaryotic DNA-binding motifs and provide an important model system for studying protein-DNA interactions. We have crystallized the Antennapedia homeodomain-DNA complex and solved this structure at 2.4 A resolution. NMR and molecular dynamics studies had implied that this homeodomain achieves specificity through an ensemble of rapidly fluctuating DNA contacts. The crystal structure is in agreement with the underlying NMR data, but our structure reveals a well-defined set of contacts and also reveals the locations and roles of water molecules at the protein-DNA interface. The synthesis of X-ray and NMR studies provides a unified, general model for homeodomain-DNA interactions.
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<!--
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Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex.,Fraenkel E, Pabo CO Nat Struct Biol. 1998 Aug;5(8):692-7. PMID:9699632<ref>PMID:9699632</ref>
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The line below this paragraph, containing "STRUCTURE_9ant", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_9ant| PDB=9ant | SCENE= }}
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===ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9699632}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9699632 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_9699632}}
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==About this Structure==
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9ANT is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ANT OCA].
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==Reference==
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<ref group="xtra">PMID:9699632</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Fraenkel, E.]]
[[Category: Fraenkel, E.]]
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Homeodomain]]
[[Category: Homeodomain]]
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[[Category: Transcription-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:12:44 2009''
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Revision as of 09:18, 5 June 2014

ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX

9ant, resolution 2.40Å

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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