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1n0w
From Proteopedia
(Difference between revisions)
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[[Image:1n0w.png|left|200px]] | [[Image:1n0w.png|left|200px]] | ||
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===Crystal structure of a RAD51-BRCA2 BRC repeat complex=== | ===Crystal structure of a RAD51-BRCA2 BRC repeat complex=== | ||
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{{ABSTRACT_PUBMED_12442171}} | {{ABSTRACT_PUBMED_12442171}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Breast cancer 2, early onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Fanconi anemia, complementation group D1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Prostate cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Wilms tumor OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Breast cancer, male, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Glioblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Medulloblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Pre-B-cell acute lymphoblastic leukemia , OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1n0w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N0W OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:012442171</ref><ref group="xtra">PMID:015125839</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Anand, S.]] | [[Category: Anand, S.]] | ||
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[[Category: Breast cancer susceptibility]] | [[Category: Breast cancer susceptibility]] | ||
[[Category: Dna repair]] | [[Category: Dna repair]] | ||
| + | [[Category: Gene regulation-antitumor protein complex]] | ||
[[Category: Homologous recombination]] | [[Category: Homologous recombination]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Reca-like atpase]] | [[Category: Reca-like atpase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:47:47 2009'' | ||
Revision as of 20:24, 5 December 2012
Crystal structure of a RAD51-BRCA2 BRC repeat complex
Template:ABSTRACT PUBMED 12442171
About this Structure
1n0w is a 4 chain structure with sequence from [1] and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature. 2002 Nov 21;420(6913):287-93. Epub 2002 Nov 10. PMID:12442171 doi:10.1038/nature01230
- Kinebuchi T, Kagawa W, Enomoto R, Tanaka K, Miyagawa K, Shibata T, Kurumizaka H, Yokoyama S. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. Mol Cell. 2004 May 7;14(3):363-74. PMID:15125839
