2g0d
From Proteopedia
(New page: 200px<br /><applet load="2g0d" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g0d, resolution 2.21Å" /> '''Nisin cyclase'''<br ...) |
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| - | [[Image:2g0d.gif|left|200px]]<br /><applet load="2g0d" size=" | + | [[Image:2g0d.gif|left|200px]]<br /><applet load="2g0d" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2g0d, resolution 2.21Å" /> | caption="2g0d, resolution 2.21Å" /> | ||
'''Nisin cyclase'''<br /> | '''Nisin cyclase'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Nisin is a posttranslationally modified antimicrobial peptide that is | + | Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate. |
==About this Structure== | ==About this Structure== | ||
| - | 2G0D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2G0D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0D OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Lactococcus lactis subsp. lactis]] | [[Category: Lactococcus lactis subsp. lactis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Nair, S | + | [[Category: Nair, S K.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: alpha barrel]] | [[Category: alpha barrel]] | ||
[[Category: alpha toroid]] | [[Category: alpha toroid]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:56 2008'' |
Revision as of 15:27, 21 February 2008
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Nisin cyclase
Overview
Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
About this Structure
2G0D is a Single protein structure of sequence from Lactococcus lactis subsp. lactis with as ligand. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:16527981
Page seeded by OCA on Thu Feb 21 17:26:56 2008
