2g0l
From Proteopedia
(New page: 200px<br /><applet load="2g0l" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g0l" /> '''Solution Structure of Neocarzinostatin Apo-P...) |
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| - | [[Image:2g0l.gif|left|200px]]<br /><applet load="2g0l" size=" | + | [[Image:2g0l.gif|left|200px]]<br /><applet load="2g0l" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2g0l" /> | caption="2g0l" /> | ||
'''Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone'''<br /> | '''Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2G0L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus] with FLN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2G0L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus] with <scene name='pdbligand=FLN:'>FLN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0L OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Streptomyces carzinostaticus]] | [[Category: Streptomyces carzinostaticus]] | ||
[[Category: Caddick, S.]] | [[Category: Caddick, S.]] | ||
| - | [[Category: Muskett, F | + | [[Category: Muskett, F W.]] |
| - | [[Category: Stoneman, R | + | [[Category: Stoneman, R G.]] |
| - | [[Category: Woolfson, D | + | [[Category: Woolfson, D N.]] |
[[Category: FLN]] | [[Category: FLN]] | ||
[[Category: beta sandwich]] | [[Category: beta sandwich]] | ||
[[Category: igg fold]] | [[Category: igg fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:57 2008'' |
Revision as of 15:26, 21 February 2008
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Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone
Overview
Neocarzinostatin (NCS) is a 1:1 complex of an enediyne chromophore (NCSChrom), non-covalently bound to an 11 kDa protein (apoNCS). We are exploring apoNCS as a generic protein system for sequestering small molecules for therapeutic applications. Here, we disclose a new flavone ligand 1 for apoNCS and present a high-resolution NMR structure of this ligand bound to apoNCS. This is the first high-resolution structure of a completely non-cognate ligand bound to the apoNCS protein. This work provides unambiguous evidence that a completely new class of ligand can bind specifically to apoNCS. Furthermore, the mode of binding is different than that of the naphthoate-based ligands, and for such a simple hydrophobic compound, the new ligand surprisingly binds specifically. This work indicates that apo-Neocarzinostatin has multiple selective and distinct binding modes for small-molecule cargo.
About this Structure
2G0L is a Single protein structure of sequence from Streptomyces carzinostaticus with as ligand. Full crystallographic information is available from OCA.
Reference
Synthetic ligands for apo-neocarzinostatin., Caddick S, Muskett FW, Stoneman RG, Woolfson DN, J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:16568976
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