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2g7c
From Proteopedia
(New page: 200px<br /><applet load="2g7c" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g7c, resolution 2.0Å" /> '''Clostridium difficile...) |
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| - | [[Image:2g7c.gif|left|200px]]<br /><applet load="2g7c" size=" | + | [[Image:2g7c.gif|left|200px]]<br /><applet load="2g7c" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2g7c, resolution 2.0Å" /> | caption="2g7c, resolution 2.0Å" /> | ||
'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''<br /> | '''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Clostridium difficile TcdA is a large toxin that binds carbohydrates on | + | Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics. |
==About this Structure== | ==About this Structure== | ||
| - | 2G7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2G7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7C OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Greco, A.]] | [[Category: Greco, A.]] | ||
| - | [[Category: Ho, J | + | [[Category: Ho, J G.S.]] |
| - | [[Category: Lin, S | + | [[Category: Lin, S J.]] |
| - | [[Category: Ng, K | + | [[Category: Ng, K K.S.]] |
| - | [[Category: Palcic, M | + | [[Category: Palcic, M M.]] |
[[Category: Rupnik, M.]] | [[Category: Rupnik, M.]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
| Line 24: | Line 24: | ||
[[Category: protein-carbohydrate complex]] | [[Category: protein-carbohydrate complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:28:51 2008'' |
Revision as of 15:28, 21 February 2008
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Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc
Overview
Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.
About this Structure
2G7C is a Single protein structure of sequence from Clostridium difficile with as ligand. Full crystallographic information is available from OCA.
Reference
Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409
Page seeded by OCA on Thu Feb 21 17:28:51 2008
