2g7h
From Proteopedia
(New page: 200px<br /><applet load="2g7h" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g7h" /> '''Structure of an O6-Methylguanine DNA Methylt...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2g7h.gif|left|200px]]<br /><applet load="2g7h" size=" | + | [[Image:2g7h.gif|left|200px]]<br /><applet load="2g7h" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2g7h" /> | caption="2g7h" /> | ||
'''Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)'''<br /> | '''Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the | + | The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the thermophile Methanococcus jannaschii has been determined using multinuclear multidimensional NMR spectroscopy. The structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain. The C-terminal domain is more highly conserved in both sequence and structure. Regions of the protein show broadening, reflecting conformational flexibility that is likely related to function. |
==About this Structure== | ==About this Structure== | ||
| - | 2G7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Active as [http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] Full crystallographic information is available from [http:// | + | 2G7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Active as [http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7H OCA]. |
==Reference== | ==Reference== | ||
| Line 20: | Line 20: | ||
[[Category: protein structure]] | [[Category: protein structure]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:01 2008'' |
Revision as of 15:29, 21 February 2008
|
Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)
Overview
The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the thermophile Methanococcus jannaschii has been determined using multinuclear multidimensional NMR spectroscopy. The structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain. The C-terminal domain is more highly conserved in both sequence and structure. Regions of the protein show broadening, reflecting conformational flexibility that is likely related to function.
About this Structure
2G7H is a Single protein structure of sequence from Methanocaldococcus jannaschii. Active as [protein-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number 2.1.1.63 Full crystallographic information is available from OCA.
Reference
Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase., Roberts A, Pelton JG, Wemmer DE, Magn Reson Chem. 2006 Jul;44 Spec No:S71-82. PMID:16826543[[Category: Methylated-DNA--[protein]-cysteine S-methyltransferase]]
Page seeded by OCA on Thu Feb 21 17:29:01 2008
