This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1xxd
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:1xxd.png|left|200px]] | [[Image:1xxd.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_1xxd", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_1xxd| PDB=1xxd | SCENE= }} | {{STRUCTURE_1xxd| PDB=1xxd | SCENE= }} | ||
===Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin=== | ===Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_15545266}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 15545266 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_15545266}} | {{ABSTRACT_PUBMED_15545266}} | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]], Factor XI deficiency, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1xxd]] is a 4 chain structure of [[Ecotin]] and [[Factor XIa]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXD OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[Ecotin|Ecotin]] | ||
| + | *[[Factor XIa|Factor XIa]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015545266</ref><ref group="xtra">PMID:015996948</ref><references group="xtra"/> |
[[Category: Coagulation factor XIa]] | [[Category: Coagulation factor XIa]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| Line 39: | Line 28: | ||
[[Category: Strickler, J E.]] | [[Category: Strickler, J E.]] | ||
[[Category: Weaver, D T.]] | [[Category: Weaver, D T.]] | ||
| + | [[Category: Blood clotting-hydrolase inhibitor complex]] | ||
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
[[Category: Ecotin]] | [[Category: Ecotin]] | ||
[[Category: Fxia]] | [[Category: Fxia]] | ||
[[Category: Serine protein]] | [[Category: Serine protein]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:26:14 2009'' | ||
Revision as of 07:42, 27 July 2012
Contents |
Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin
Template:ABSTRACT PUBMED 15545266
About this Structure
1xxd is a 4 chain structure of Ecotin and Factor XIa with sequence from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Jin L, Pandey P, Babine RE, Gorga JC, Seidl KJ, Gelfand E, Weaver DT, Abdel-Meguid SS, Strickler JE. Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions. J Biol Chem. 2005 Feb 11;280(6):4704-12. Epub 2004 Nov 15. PMID:15545266 doi:10.1074/jbc.M411309200
- Takamiya O, Machida S, Yamamoto M. Factor XI deficiency with a novel homozygous mutation Trp599Arg near the C-terminal region. Haematologica. 2005 Jul;90(7):999-1001. PMID:15996948
