2ggc
From Proteopedia
(New page: 200px<br /><applet load="2ggc" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ggc, resolution 1.000Å" /> '''Novel bacterial met...) |
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| - | [[Image:2ggc.gif|left|200px]]<br /><applet load="2ggc" size=" | + | [[Image:2ggc.gif|left|200px]]<br /><applet load="2ggc" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ggc, resolution 1.000Å" /> | caption="2ggc, resolution 1.000Å" /> | ||
'''Novel bacterial methionine aminopeptidase inhibitors'''<br /> | '''Novel bacterial methionine aminopeptidase inhibitors'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GGC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CO, NA and MET as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http:// | + | 2GGC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CO:'>CO</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=MET:'>MET</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: pita-bread fold]] | [[Category: pita-bread fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:30:28 2008'' |
Revision as of 13:30, 23 January 2008
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Novel bacterial methionine aminopeptidase inhibitors
Overview
In this article we describe the application of structural biology methods, to the discovery of novel potent inhibitors of methionine aminopeptidases., These enzymes are employed by the cells to cleave the N-terminal, methionine from nascent peptides and proteins. As this is one of the, critical steps in protein maturation, it is very likely that inhibitors of, these enzymes may prove useful as novel antibacterial agents. Involvement, of crystallography at the very early stages of the inhibitor design, process resulted in serendipitous discovery of a new inhibitor class, the, pyrazole-diamines. Atomic-resolution structures of several inhibitors, bound to the enzyme illuminate a new mode of inhibitor binding.
About this Structure
2GGC is a Single protein structure of sequence from Escherichia coli with , and as ligands. Active as Methionyl aminopeptidase, with EC number 3.4.11.18 Full crystallographic information is available from OCA.
Reference
Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors., Evdokimov AG, Pokross M, Walter RL, Mekel M, Barnett BL, Amburgey J, Seibel WL, Soper SJ, Djung JF, Fairweather N, Diven C, Rastogi V, Grinius L, Klanke C, Siehnel R, Twinem T, Andrews R, Curnow A, Proteins. 2007 Feb 15;66(3):538-46. PMID:17120228
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