2ggp
From Proteopedia
(New page: 200px<br /><applet load="2ggp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ggp" /> '''Solution structure of the Atx1-Cu(I)-Ccc2a c...) |
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| - | [[Image:2ggp.gif|left|200px]]<br /><applet load="2ggp" size=" | + | [[Image:2ggp.gif|left|200px]]<br /><applet load="2ggp" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ggp" /> | caption="2ggp" /> | ||
'''Solution structure of the Atx1-Cu(I)-Ccc2a complex'''<br /> | '''Solution structure of the Atx1-Cu(I)-Ccc2a complex'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Cellular systems allow transition-metal ions to reach or leave the cell or | + | Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling mutagenesis and advanced NMR experiments, we structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase. Copper was required for the interaction. This study provides an understanding of metal-mediated protein-protein interactions in which the metal ion is essential for the weak, reversible interaction between the partners. |
==About this Structure== | ==About this Structure== | ||
| - | 2GGP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with CU1 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] Full crystallographic information is available from [http:// | + | 2GGP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=CU1:'>CU1</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bertini, I.]] | [[Category: Bertini, I.]] | ||
[[Category: Cantini, F.]] | [[Category: Cantini, F.]] | ||
| - | [[Category: Felli, I | + | [[Category: Felli, I C.]] |
[[Category: Gonnelli, L.]] | [[Category: Gonnelli, L.]] | ||
[[Category: Hadjiliadis, N.]] | [[Category: Hadjiliadis, N.]] | ||
[[Category: Pierattelli, R.]] | [[Category: Pierattelli, R.]] | ||
[[Category: Rosato, A.]] | [[Category: Rosato, A.]] | ||
| - | [[Category: SPINE, Structural | + | [[Category: SPINE, Structural Proteomics in Europe.]] |
[[Category: Voulgaris, P.]] | [[Category: Voulgaris, P.]] | ||
[[Category: CU1]] | [[Category: CU1]] | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:31:31 2008'' |
Revision as of 15:31, 21 February 2008
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Solution structure of the Atx1-Cu(I)-Ccc2a complex
Overview
Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling mutagenesis and advanced NMR experiments, we structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase. Copper was required for the interaction. This study provides an understanding of metal-mediated protein-protein interactions in which the metal ion is essential for the weak, reversible interaction between the partners.
About this Structure
2GGP is a Protein complex structure of sequences from Saccharomyces cerevisiae with as ligand. Active as Copper-exporting ATPase, with EC number 3.6.3.4 Full crystallographic information is available from OCA.
Reference
The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction., Banci L, Bertini I, Cantini F, Felli IC, Gonnelli L, Hadjiliadis N, Pierattelli R, Rosato A, Voulgaris P, Nat Chem Biol. 2006 Jul;2(7):367-8. Epub 2006 May 28. PMID:16732294
Page seeded by OCA on Thu Feb 21 17:31:31 2008
Categories: Copper-exporting ATPase | Protein complex | Saccharomyces cerevisiae | Banci, L. | Bertini, I. | Cantini, F. | Felli, I C. | Gonnelli, L. | Hadjiliadis, N. | Pierattelli, R. | Rosato, A. | SPINE, Structural Proteomics in Europe. | Voulgaris, P. | CU1 | Complex | Copper transport | Nmr | Spine | Structural genomics | Structural proteomics in europe
