2rfn
From Proteopedia
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[[Image:2rfn.png|left|200px]] | [[Image:2rfn.png|left|200px]] | ||
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{{STRUCTURE_2rfn| PDB=2rfn | SCENE= }} | {{STRUCTURE_2rfn| PDB=2rfn | SCENE= }} | ||
===x-ray structure of c-Met with inhibitor.=== | ===x-ray structure of c-Met with inhibitor.=== | ||
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| - | (as it appears on PubMed at http://www.pubmed.gov), where 18055465 is the PubMed ID number. | ||
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{{ABSTRACT_PUBMED_18055465}} | {{ABSTRACT_PUBMED_18055465}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2rfn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFN OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018055465</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:58:26 2009'' | ||
Revision as of 22:15, 7 January 2013
x-ray structure of c-Met with inhibitor.
Template:ABSTRACT PUBMED 18055465
About this Structure
2rfn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bellon SF, Kaplan-Lefko P, Yang Y, Zhang Y, Moriguchi J, Rex K, Johnson CW, Rose PE, Long AM, O'Connor AB, Gu Y, Coxon A, Kim TS, Tasker A, Burgess TL, Dussault I. c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J Biol Chem. 2008 Feb 1;283(5):2675-83. Epub 2007 Nov 30. PMID:18055465 doi:10.1074/jbc.M705774200
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Bellon, S F. | Dussault, I. | Kaplan-Lefko, P. | Moriguchi, J. | Yang, Y. | Zhang, Y. | Atp-binding | C-met hgf receptor tyrosine kinse kinase domain | Glycoprotein | Membrane | Nucleotide-binding | Phosphorylation | Proto-oncogene | Transferase | Transmembrane | Tyrosine-protein kinase
