2bio
From Proteopedia
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[[Image:2bio.png|left|200px]] | [[Image:2bio.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2bio]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIO OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:15703170</ref><references group="xtra"/> | + | <ref group="xtra">PMID:15703170</ref><ref group="xtra">PMID:14534297</ref><ref group="xtra">PMID:8023157</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fersht, A R.]] | [[Category: Fersht, A R.]] | ||
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[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:02:14 2009'' | ||
Revision as of 22:21, 14 March 2011
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-R249S-N268D
Template:ABSTRACT PUBMED 15703170
About this Structure
2bio is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 1994 Jul 15;265(5170):346-55. PMID:8023157
Categories: Homo sapiens | Fersht, A R. | Joerger, A C. | 3d-structure | Activator | Anti-oncogene | Apoptosis | Disease mutation | Dna-binding | Dna-binding protein | Li-fraumeni syndrome | Nuclear protein | P53 dna-binding domain | Phosphorylation | Polymorphism | Second-site suppressor mutation | Superstable mutant | Transcription regulation | Tumor suppressor
