1jnq
From Proteopedia
(New page: 200px<br /> <applet load="1jnq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jnq, resolution 2.1Å" /> '''LIPOXYGENASE-3 (SOYB...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1JNQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Glycine_max Glycine max]] with FE2 and EGT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JNQ OCA]]. | + | 1JNQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Glycine_max Glycine max]] with FE2 and EGT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12]]. Structure known Active Site: FE. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JNQ OCA]]. |
==Reference== | ==Reference== | ||
Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead., Skrzypczak-Jankun E, Zhou K, Jankun J, Int J Mol Med. 2003 Oct;12(4):415-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12964012 12964012] | Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead., Skrzypczak-Jankun E, Zhou K, Jankun J, Int J Mol Med. 2003 Oct;12(4):415-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12964012 12964012] | ||
[[Category: Glycine max]] | [[Category: Glycine max]] | ||
| + | [[Category: Lipoxygenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Jankun, J.]] | [[Category: Jankun, J.]] | ||
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[[Category: purple lipoxygenase]] | [[Category: purple lipoxygenase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:27:08 2007'' |
Revision as of 12:22, 30 October 2007
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LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)
Overview
Lipoxygenases (LOXs) are non-heme iron containing enzymes ubiquitous in, nature and participating in the metabolism of the polyunsaturated fatty, acids (PUFA). They are capable of combining their dioxygenase activity, with its co-oxidative activity manifesting itself in biotransformation, reactions catalyzed by LOXs for other than PUFA small molecules. LOXs, involvement in inflammatory diseases and cancer have been well documented., Catechins are the natural flavonoids of known inhibitory activity toward, dioxygenases with a potential to be utilized in disease prevention and, treatment. This work presents results obtained from an X-ray analysis of, (-)-epigallocatechin gallate (EGCG) interacting with soybean, lipoxygenase-3. The 3D structure of the resulting complex reveals the, inhibitor ... [(full description)]
About this Structure
1JNQ is a [Single protein] structure of sequence from [Glycine max] with FE2 and EGT as [ligands]. Active as [Lipoxygenase], with EC number [1.13.11.12]. Structure known Active Site: FE. Full crystallographic information is available from [OCA].
Reference
Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead., Skrzypczak-Jankun E, Zhou K, Jankun J, Int J Mol Med. 2003 Oct;12(4):415-20. PMID:12964012
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