1qmh
From Proteopedia
(New page: 200px<br /> <applet load="1qmh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qmh, resolution 2.1Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1QMH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with CIT and DTO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.4 6.5.1.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QMH OCA]]. | + | 1QMH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with CIT and DTO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/RNA-3'-phosphate_cyclase RNA-3'-phosphate cyclase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.4 6.5.1.4]]. Structure known Active Sites: RB1 and RB2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QMH OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology., Palm GJ, Billy E, Filipowicz W, Wlodawer A, Structure. 2000 Jan 15;8(1):13-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10673421 10673421] | Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology., Palm GJ, Billy E, Filipowicz W, Wlodawer A, Structure. 2000 Jan 15;8(1):13-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10673421 10673421] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| + | [[Category: RNA-3'-phosphate cyclase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Billy, E.]] | [[Category: Billy, E.]] | ||
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[[Category: rna 3'-terminal phosphate cyclase]] | [[Category: rna 3'-terminal phosphate cyclase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:27:14 2007'' |
Revision as of 12:22, 30 October 2007
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CRYSTAL STRUCTURE OF RNA 3'-TERMINAL PHOSPHATE CYCLASE, AN UBIQUITOUS ENZYME WITH UNUSUAL TOPOLOGY
Overview
BACKGROUND: RNA cyclases are a family of RNA-modifying enzymes that are, conserved in eucarya, bacteria and archaea. They catalyze the, ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic, phosphodiester at the end of RNA, in a reaction involving formation of the, covalent AMP-cyclase intermediate. These enzymes might be responsible for, production of the cyclic phosphate RNA ends that are known to be required, by many RNA ligases in both prokaryotes and eukaryotes. RESULTS: The, high-resolution structure of the Escherichia coli RNA 3'-terminal, phosphate cyclase was determined using multiwavelength anomalous, diffraction. Two orthorhombic crystal forms of E. coli cyclase (space, group P2(1)2(1)2(1) and P2(1)2(1)2) were used to solve and refine the, structure to 2.1 A ... [(full description)]
About this Structure
1QMH is a [Single protein] structure of sequence from [Escherichia coli] with CIT and DTO as [ligands]. Active as [RNA-3'-phosphate cyclase], with EC number [6.5.1.4]. Structure known Active Sites: RB1 and RB2. Full crystallographic information is available from [OCA].
Reference
Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology., Palm GJ, Billy E, Filipowicz W, Wlodawer A, Structure. 2000 Jan 15;8(1):13-23. PMID:10673421
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