2h6t
From Proteopedia
(New page: 200px<br /><applet load="2h6t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2h6t, resolution 1.900Å" /> '''Secreted aspartic p...) |
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| - | [[Image:2h6t.jpg|left|200px]]<br /><applet load="2h6t" size=" | + | [[Image:2h6t.jpg|left|200px]]<br /><applet load="2h6t" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2h6t, resolution 1.900Å" /> | caption="2h6t, resolution 1.900Å" /> | ||
'''Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A'''<br /> | '''Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2H6T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with ZN and IHN as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] Full crystallographic information is available from [http:// | + | 2H6T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=IHN:'>IHN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6T OCA]. |
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:31:35 2008'' |
Revision as of 10:31, 23 January 2008
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Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A
Overview
The family of secreted aspartic proteinases (Sap) encoded by 10 SAP genes, is an important virulence factor during Candida albicans (C. albicans), infections. Antagonists to Saps could be envisioned to help prevent or, treat candidosis in immunocompromised patients. The knowledge of several, Sap structures is crucial for inhibitor design; only the structure of Sap2, is known. We report the 1.9 and 2.2 A resolution X-ray crystal structures, of Sap3 in a stable complex with pepstatin A and in the absence of an, inhibitor, shedding further light on the enzyme inhibitor binding., Inhibitor binding causes active site closure by the movement of a flap, segment. Comparison of the structures of Sap3 and Sap2 identifies elements, responsible for the specificity of each isoenzyme. Proteins 2007. (c) 2007, Wiley-Liss, Inc.
About this Structure
2H6T is a Single protein structure of sequence from Candida albicans with and as ligands. Active as Candidapepsin, with EC number 3.4.23.24 Full crystallographic information is available from OCA.
Reference
The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A., Borelli C, Ruge E, Schaller M, Monod M, Christian Korting H, Huber R, Maskos K, Proteins. 2007 May 17;. PMID:17510964
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Categories: Candida albicans | Candidapepsin | Single protein | Borelli, C. | Huber, R. | Maskos, K. | Ruge, E. | IHN | ZN | Aspartic proteinase | Hydrolase
