2viw
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2viw.png|left|200px]] | [[Image:2viw.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2viw", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2viw| PDB=2viw | SCENE= }} | {{STRUCTURE_2viw| PDB=2viw | SCENE= }} | ||
===FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR=== | ===FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_18163548}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18163548 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_18163548}} | {{ABSTRACT_PUBMED_18163548}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2viw]] is a 1 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIW OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[Urokinase|Urokinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018163548</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: U-plasminogen activator]] | [[Category: U-plasminogen activator]] | ||
| Line 43: | Line 34: | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Kringle]] | [[Category: Kringle]] | ||
| - | [[Category: Pharmaceutical]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Plasminogen activation]] | [[Category: Plasminogen activation]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
| Line 52: | Line 41: | ||
[[Category: Urokinase-type plasminogen activator]] | [[Category: Urokinase-type plasminogen activator]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:38:24 2009'' | ||
Revision as of 12:03, 27 July 2012
Contents |
FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Template:ABSTRACT PUBMED 18163548
About this Structure
2viw is a 1 chain structure of Urokinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Frederickson M, Callaghan O, Chessari G, Congreve M, Cowan SR, Matthews JE, McMenamin R, Smith DM, Vinkovic M, Wallis NG. Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator. J Med Chem. 2008 Jan 24;51(2):183-6. Epub 2007 Dec 29. PMID:18163548 doi:http://dx.doi.org/10.1021/jm701359z
Categories: Homo sapiens | U-plasminogen activator | Callaghan, O. | Chessari, G. | Congreve, M. | Cowan, S R. | Frederickson, M. | Matthews, J E. | Mcmenamin, R. | Smith, D. | Vinkovic, M. | Wallis, N G. | Blood coagulation | Egf-like domain | Fibrinolysis | Glycoprotein | Hydrolase | Inhibitor | Kringle | Phosphorylation | Plasminogen activation | Protease | Secreted | Serine protease | Urokinase-type plasminogen activator | Zymogen
