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2nxt
From Proteopedia
(Difference between revisions)
| Line 33: | Line 33: | ||
[[Category: Carbonic anhydrase]] | [[Category: Carbonic anhydrase]] | ||
[[Category: Histidine 64]] | [[Category: Histidine 64]] | ||
| + | [[Category: Lyase]] | ||
[[Category: Proton transfer]] | [[Category: Proton transfer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 8 20:09:16 2009'' |
Revision as of 17:09, 8 April 2009
Contents |
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Template:ABSTRACT PUBMED 17330962
Disease
Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]
About this Structure
2NXT is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Fisher SZ, Tu C, Bhatt D, Govindasamy L, Agbandje-McKenna M, McKenna R, Silverman DN. Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II. Biochemistry. 2007 Mar 27;46(12):3803-13. Epub 2007 Mar 2. PMID:17330962 doi:10.1021/bi602620k
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