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1gsz
From Proteopedia
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[[Image:1gsz.png|left|200px]] | [[Image:1gsz.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[1gsz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSZ OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:12031670</ref><references group="xtra"/> | + | <ref group="xtra">PMID:12031670</ref><ref group="xtra">PMID:9931258</ref><ref group="xtra">PMID:9295270</ref><ref group="xtra">PMID:9070455</ref><ref group="xtra">PMID:9162756</ref><references group="xtra"/> |
[[Category: Alicyclobacillus acidocaldarius]] | [[Category: Alicyclobacillus acidocaldarius]] | ||
[[Category: Lenhart, A.]] | [[Category: Lenhart, A.]] | ||
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[[Category: Monotopic membrane protein]] | [[Category: Monotopic membrane protein]] | ||
[[Category: Oxidosqualene cyclase]] | [[Category: Oxidosqualene cyclase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:48:46 2009'' | ||
Revision as of 00:36, 15 March 2011
CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071
Template:ABSTRACT PUBMED 12031670
About this Structure
1gsz is a 3 chain structure with sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.
Reference
- Lenhart A, Weihofen WA, Pleschke AE, Schulz GE. Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071. Chem Biol. 2002 May;9(5):639-45. PMID:12031670
- Wendt KU, Lenhart A, Schulz GE. The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution. J Mol Biol. 1999 Feb 12;286(1):175-87. PMID:9931258 doi:http://dx.doi.org/10.1006/jmbi.1998.2470
- Wendt KU, Poralla K, Schulz GE. Structure and function of a squalene cyclase. Science. 1997 Sep 19;277(5333):1811-5. PMID:9295270
- Wendt KU, Feil C, Lenhart A, Poralla K, Schulz GE. Crystallization and preliminary X-ray crystallographic analysis of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Protein Sci. 1997 Mar;6(3):722-4. PMID:9070455 doi:10.1002/pro.5560060322
- Morand OH, Aebi JD, Dehmlow H, Ji YH, Gains N, Lengsfeld H, Himber J. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90. PMID:9162756
