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1ca8
From Proteopedia
(New page: 200px<br /> <applet load="1ca8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ca8, resolution 2.1Å" /> '''THROMBIN INHIBITORS ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1CA8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA, PMS and NVA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CA8 OCA]]. | + | 1CA8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA, PMS and NVA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Thrombin Thrombin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CA8 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Thrombin]] | ||
[[Category: Arni, R.K.]] | [[Category: Arni, R.K.]] | ||
[[Category: Brunck, T.K.]] | [[Category: Brunck, T.K.]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:31:15 2007'' |
Revision as of 12:26, 30 October 2007
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THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES
Overview
The crystal structures of three highly potent and selective low-molecular, weight rigid peptidyl aldehyde inhibitors complexed with thrombin have, been determined and refined to R values 0.152-0. 170 at 1.8-2.1 A, resolution. Since the selectivity of two of the inhibitors was >1600 with, respect to trypsin, the structures of trypsin-inhibited complexes of these, inhibitors were also determined (R = 0.142-0.157 at 1.9-2.1 A resolution)., The selectivity appears to reside in the inability of a benzenesulfonamide, group to bind at the equivalent of the D-enantiomorphic S3 site of, thrombin, which may be related to the lack of a 60-insertion loop in, trypsin. All the inhibitors have a novel lactam moiety at the P3 position, while the two with greatest trypsin selectivity have a ... [(full description)]
About this Structure
1CA8 is a [Single protein] structure of sequence from [Homo sapiens] with NA, PMS and NVA as [ligands]. Active as [Thrombin], with EC number [3.4.21.5]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes., Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK, Biochemistry. 1998 Sep 1;37(35):12094-103. PMID:9724521
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