3fr0

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Revision as of 17:06, 8 April 2009

Image:3fr0.png

Template:STRUCTURE 3fr0

Human glucokinase in complex with 2-amino benzamide activator

Template:ABSTRACT PUBMED 19188063

About this Structure

3FR0 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nishimura T, Iino T, Mitsuya M, Bamba M, Watanabe H, Tsukahara D, Kamata K, Sasaki K, Ohyama S, Hosaka H, Futamura M, Nagata Y, Eiki J. Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1357-60. Epub 2009 Jan 21. PMID:19188063 doi:10.1016/j.bmcl.2009.01.053
  • Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure. 2004 Mar;12(3):429-38. PMID:15016359 doi:10.1016/j.str.2004.02.005

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