1oyt
From Proteopedia
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[[Image:1oyt.png|left|200px]] | [[Image:1oyt.png|left|200px]] | ||
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{{STRUCTURE_1oyt| PDB=1oyt | SCENE= }} | {{STRUCTURE_1oyt| PDB=1oyt | SCENE= }} | ||
===COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR=== | ===COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR=== | ||
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- | ==Disease== | ||
- | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
- | + | [[1oyt]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYT OCA]. | |
+ | |||
+ | ==See Also== | ||
+ | *[[Hirudin|Hirudin]] | ||
+ | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
- | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:012800172</ref><references group="xtra"/> |
+ | [[Category: Hirudo medicinalis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Banner, D W.]] | [[Category: Banner, D W.]] | ||
[[Category: Olsen, J A.]] | [[Category: Olsen, J A.]] | ||
- | + | [[Category: Hydrolase-hydrolase inhibitor complex]] | |
- | + | [[Category: Serine proteinase]] |
Revision as of 15:28, 27 July 2012
Contents |
COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR
About this Structure
1oyt is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F. A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions. Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:12800172 doi:10.1002/anie.200351268