3znf

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[[Image:3znf.png|left|200px]]
 
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{{STRUCTURE_3znf| PDB=3znf | SCENE= }}
{{STRUCTURE_3znf| PDB=3znf | SCENE= }}
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===HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION===
===HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION===
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{{ABSTRACT_PUBMED_2248949}}
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==Function==
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[[http://www.uniprot.org/uniprot/ZEP1_HUMAN ZEP1_HUMAN]] This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.[:]<ref>PMID:1727488</ref> <ref>PMID:8289330</ref> <ref>PMID:11818340</ref>
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{{ABSTRACT_PUBMED_2248949}}
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==About this Structure==
==About this Structure==
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3ZNF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNF OCA].
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[[3znf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNF OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:2248949</ref><references group="xtra"/>
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<ref group="xtra">PMID:002248949</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Clore, G M.]]
[[Category: Clore, G M.]]
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[[Category: Omichinski, J G.]]
[[Category: Omichinski, J G.]]
[[Category: Zinc finger dna binding domain]]
[[Category: Zinc finger dna binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:58:30 2009''
 

Revision as of 07:45, 16 May 2013

Template:STRUCTURE 3znf

Contents

HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION

Template:ABSTRACT PUBMED 2248949

Function

[ZEP1_HUMAN] This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.[:][1] [2] [3]

About this Structure

3znf is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Omichinski JG, Clore GM, Appella E, Sakaguchi K, Gronenborn AM. High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry. 1990 Oct 9;29(40):9324-34. PMID:2248949
  1. ↑ Muchardt C, Seeler JS, Nirula A, Shurland DL, Gaynor RB. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. J Virol. 1992 Jan;66(1):244-50. PMID:1727488
  2. ↑ Seeler JS, Muchardt C, Suessle A, Gaynor RB. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. J Virol. 1994 Feb;68(2):1002-9. PMID:8289330
  3. ↑ Lallemand C, Palmieri M, Blanchard B, Meritet JF, Tovey MG. GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity. EMBO Rep. 2002 Feb;3(2):153-8. Epub 2002 Jan 29. PMID:11818340 doi:10.1093/embo-reports/kvf032

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