This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3znf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3znf.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3znf", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3znf| PDB=3znf | SCENE= }}
{{STRUCTURE_3znf| PDB=3znf | SCENE= }}
- 
===HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION===
===HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION===
 +
{{ABSTRACT_PUBMED_2248949}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/ZEP1_HUMAN ZEP1_HUMAN]] This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.[:]<ref>PMID:1727488</ref> <ref>PMID:8289330</ref> <ref>PMID:11818340</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_2248949}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 2248949 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_2248949}}
+
==About this Structure==
==About this Structure==
-
3ZNF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNF OCA].
+
[[3znf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNF OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:2248949</ref><references group="xtra"/>
+
<ref group="xtra">PMID:002248949</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Clore, G M.]]
[[Category: Clore, G M.]]
Line 29: Line 16:
[[Category: Omichinski, J G.]]
[[Category: Omichinski, J G.]]
[[Category: Zinc finger dna binding domain]]
[[Category: Zinc finger dna binding domain]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:58:30 2009''
 

Revision as of 07:45, 16 May 2013

Template:STRUCTURE 3znf

Contents

HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION

Template:ABSTRACT PUBMED 2248949

Function

[ZEP1_HUMAN] This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.[:][1] [2] [3]

About this Structure

3znf is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Omichinski JG, Clore GM, Appella E, Sakaguchi K, Gronenborn AM. High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry. 1990 Oct 9;29(40):9324-34. PMID:2248949
  1. ↑ Muchardt C, Seeler JS, Nirula A, Shurland DL, Gaynor RB. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. J Virol. 1992 Jan;66(1):244-50. PMID:1727488
  2. ↑ Seeler JS, Muchardt C, Suessle A, Gaynor RB. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. J Virol. 1994 Feb;68(2):1002-9. PMID:8289330
  3. ↑ Lallemand C, Palmieri M, Blanchard B, Meritet JF, Tovey MG. GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity. EMBO Rep. 2002 Feb;3(2):153-8. Epub 2002 Jan 29. PMID:11818340 doi:10.1093/embo-reports/kvf032

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3znf"
Personal tools