2jhb
From Proteopedia
(New page: 200px<br /><applet load="2jhb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jhb" /> '''CORE BINDING FACTOR BETA'''<br /> ==Overvie...) |
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| - | [[Image:2jhb.jpg|left|200px]]<br /><applet load="2jhb" size=" | + | [[Image:2jhb.jpg|left|200px]]<br /><applet load="2jhb" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''CORE BINDING FACTOR BETA'''<br /> | '''CORE BINDING FACTOR BETA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The core binding factor beta subunit (CBF beta) is the non-DNA binding | + | The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development. Chromosomal translocations involving the human CBFB gene are associated with a large percentage of human leukemias. The N-terminal 141 amino acids of CBF beta contains the heterodimerization domain for the DNA-binding CBF alpha subunits, and is sufficient for CBF beta function in vivo. Here we present the high-resolution solution structure of the CBF beta heterodimerization domain. It is a novel alpha/beta structure consisting of two three-stranded beta-sheets packed on one another in a sandwich arrangement, with four peripheral alpha-helices. The CBF alpha binding site on CBF beta has been mapped by chemical shift perturbation analysis. |
==About this Structure== | ==About this Structure== | ||
| - | 2JHB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 2JHB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bushweller, J | + | [[Category: Bushweller, J H.]] |
[[Category: Huang, X.]] | [[Category: Huang, X.]] | ||
[[Category: Peng, J.]] | [[Category: Peng, J.]] | ||
| - | [[Category: Speck, N | + | [[Category: Speck, N A.]] |
[[Category: core binding factor]] | [[Category: core binding factor]] | ||
[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:03:16 2008'' |
Revision as of 16:03, 21 February 2008
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CORE BINDING FACTOR BETA
Overview
The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development. Chromosomal translocations involving the human CBFB gene are associated with a large percentage of human leukemias. The N-terminal 141 amino acids of CBF beta contains the heterodimerization domain for the DNA-binding CBF alpha subunits, and is sufficient for CBF beta function in vivo. Here we present the high-resolution solution structure of the CBF beta heterodimerization domain. It is a novel alpha/beta structure consisting of two three-stranded beta-sheets packed on one another in a sandwich arrangement, with four peripheral alpha-helices. The CBF alpha binding site on CBF beta has been mapped by chemical shift perturbation analysis.
About this Structure
2JHB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Solution structure of core binding factor beta and map of the CBF alpha binding site., Huang X, Peng JW, Speck NA, Bushweller JH, Nat Struct Biol. 1999 Jul;6(7):624-7. PMID:10404216
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