1ayz
From Proteopedia
(New page: 200px<br /> <applet load="1ayz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ayz, resolution 2.60Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1AYZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AYZ OCA]]. | + | 1AYZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]]. Active as [[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]]. Structure known Active Site: NUL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AYZ OCA]]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Ubiquitin--protein ligase]] | ||
[[Category: Hill, C.P.]] | [[Category: Hill, C.P.]] | ||
[[Category: Prakash, L.]] | [[Category: Prakash, L.]] | ||
| Line 21: | Line 22: | ||
[[Category: ubiquitin-conjugating enzyme]] | [[Category: ubiquitin-conjugating enzyme]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:34:54 2007'' |
Revision as of 12:30, 30 October 2007
|
CRYSTAL STRUCTURE OF THE SACCHAROMYCES CEREVISIAE UBIQUITIN-CONJUGATING ENZYME RAD6 (UBC2) AT 2.6A RESOLUTION
Overview
The Saccharomyces cerevisiae ubiquitin-conjugating enzyme (UBC) Rad6 is, required for several functions, including the repair of UV damaged DNA, damage-induced mutagenesis, sporulation, and the degradation of cellular, proteins that possess destabilizing N-terminal residues. Rad6 mediates its, role in N-end rule-dependent protein degradation via interaction with the, ubiquitin-protein ligase Ubr1 and in DNA repair via interactions with the, DNA binding protein Rad18. We report here the crystal structure of Rad6, refined at 2.6 A resolution to an R factor of 21.3%. The protein adopts an, alpha/beta fold that is very similar to other UBC structures. An apparent, difference at the functionally important first helix, however, has, prompted a reassessment of previously reported structures. The ... [(full description)]
About this Structure
1AYZ is a [Single protein] structure of sequence from [Saccharomyces cerevisiae]. Active as [Ubiquitin--protein ligase], with EC number [6.3.2.19]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution., Worthylake DK, Prakash S, Prakash L, Hill CP, J Biol Chem. 1998 Mar 13;273(11):6271-6. PMID:9497353
Page seeded by OCA on Tue Oct 30 14:34:54 2007
