Triose Phosphate Isomerase
From Proteopedia
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Triose Phosphate Isomease Deficiency is a rare (less then 100 cases worldwide), autosomal recessive disorder first described in 1965.<Schneider, Arthur S.; William N. Valentine, Hattori M, H. L. Heins Jr (1965). "Hereditary Hemolytic Anemia with Triosephosphate Isomerase Deficiency". New England Journal of Medicine 272: 229–35> Symptoms include haemolytic anaemia, cardiomyopathy, an increased susceptibility to infections, severe neurological dysfunctions, and, often times, death in early childhood. | Triose Phosphate Isomease Deficiency is a rare (less then 100 cases worldwide), autosomal recessive disorder first described in 1965.<Schneider, Arthur S.; William N. Valentine, Hattori M, H. L. Heins Jr (1965). "Hereditary Hemolytic Anemia with Triosephosphate Isomerase Deficiency". New England Journal of Medicine 272: 229–35> Symptoms include haemolytic anaemia, cardiomyopathy, an increased susceptibility to infections, severe neurological dysfunctions, and, often times, death in early childhood. | ||
Revision as of 22:30, 18 March 2009
Triose Phosphate Isomerase (TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.
Mechanism
Acid Base Catalysis
Diagram .[1]
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Gregg Snider, Eric Martz, Michal Harel, Alexander Berchansky, David Canner, Eran Hodis, Stephen Everse, Angel Herraez, Jane S. Richardson
