2iwg
From Proteopedia
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{{STRUCTURE_2iwg| PDB=2iwg | SCENE= }} | {{STRUCTURE_2iwg| PDB=2iwg | SCENE= }} | ||
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===COMPLEX BETWEEN THE PRYSPRY DOMAIN OF TRIM21 AND IGG FC=== | ===COMPLEX BETWEEN THE PRYSPRY DOMAIN OF TRIM21 AND IGG FC=== | ||
| + | {{ABSTRACT_PUBMED_17400754}} | ||
| - | + | ==Disease== | |
| - | + | [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2iwg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWG OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017400754</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: James, L C.]] | [[Category: James, L C.]] | ||
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[[Category: Immunoglobulin domain]] | [[Category: Immunoglobulin domain]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
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[[Category: Ribonucleoprotein]] | [[Category: Ribonucleoprotein]] | ||
[[Category: Rna-binding]] | [[Category: Rna-binding]] | ||
[[Category: Systemic lupus erythematosus]] | [[Category: Systemic lupus erythematosus]] | ||
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[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:57:52 2009'' | ||
Revision as of 02:23, 25 March 2013
Contents |
COMPLEX BETWEEN THE PRYSPRY DOMAIN OF TRIM21 AND IGG FC
Template:ABSTRACT PUBMED 17400754
Disease
[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
About this Structure
2iwg is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J. Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6200-5. Epub 2007 Mar 30. PMID:17400754
