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3c09
From Proteopedia
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[[Image:3c09.png|left|200px]] | [[Image:3c09.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_18394559}} | {{ABSTRACT_PUBMED_18394559}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3c09]] is a 6 chain structure of [[Epidermal Growth Factor Receptor]] and [[Monoclonal Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Homo_sapiens,_mus_musculus Homo sapiens, mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C09 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Epidermal Growth Factor Receptor]] | ||
| + | *[[Monoclonal Antibody]] | ||
==Reference== | ==Reference== | ||
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[[Category: Fab fragment]] | [[Category: Fab fragment]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:20:43 2009'' | ||
Revision as of 21:51, 26 December 2010
Contents |
Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR
Template:ABSTRACT PUBMED 18394559
About this Structure
3c09 is a 6 chain structure of Epidermal Growth Factor Receptor and Monoclonal Antibody with sequence from Homo sapiens and Homo sapiens, mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Schmiedel J, Blaukat A, Li S, Knochel T, Ferguson KM. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 2008 Apr;13(4):365-73. PMID:18394559 doi:10.1016/j.ccr.2008.02.019
