2o4v

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(New page: 200px<br /><applet load="2o4v" size="450" color="white" frame="true" align="right" spinBox="true" caption="2o4v, resolution 1.94&Aring;" /> '''An arginine ladder i...)
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[[Image:2o4v.gif|left|200px]]<br /><applet load="2o4v" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:2o4v.gif|left|200px]]<br /><applet load="2o4v" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2o4v, resolution 1.94&Aring;" />
caption="2o4v, resolution 1.94&Aring;" />
'''An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane'''<br />
'''An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane'''<br />
==Overview==
==Overview==
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The outer membrane protein OprP mediates the transport of essential, phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa., Here we report the crystallographic structure of trimeric OprP at 1.9-A, resolution, revealing an unprecedented 9-residue arginine 'ladder' that, spans from the extracellular surface down through a constriction zone, where phosphate is coordinated. Lysine residues coat the inner periplasmic, surface, creating an 'electropositive sink' that pulls the phosphates, through the eyelet and into the cell.
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The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-A resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from the extracellular surface down through a constriction zone where phosphate is coordinated. Lysine residues coat the inner periplasmic surface, creating an 'electropositive sink' that pulls the phosphates through the eyelet and into the cell.
==About this Structure==
==About this Structure==
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2O4V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with CA, PO4, CL, C8E and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2O4V OCA].
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2O4V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=C8E:'>C8E</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4V OCA].
==Reference==
==Reference==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Bains, M.]]
[[Category: Bains, M.]]
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[[Category: Hancock, R.E.]]
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[[Category: Hancock, R E.]]
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[[Category: Moraes, T.F.]]
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[[Category: Moraes, T F.]]
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[[Category: Strynadka, N.C.]]
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[[Category: Strynadka, N C.]]
[[Category: C8E]]
[[Category: C8E]]
[[Category: CA]]
[[Category: CA]]
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[[Category: transport]]
[[Category: transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:03:19 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:14:29 2008''

Revision as of 16:14, 21 February 2008

Image:2o4v.gif

2o4v, resolution 1.94Å

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An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane

Overview

The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-A resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from the extracellular surface down through a constriction zone where phosphate is coordinated. Lysine residues coat the inner periplasmic surface, creating an 'electropositive sink' that pulls the phosphates through the eyelet and into the cell.

About this Structure

2O4V is a Single protein structure of sequence from Pseudomonas aeruginosa with , , , and as ligands. Full crystallographic information is available from OCA.

Reference

An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane., Moraes TF, Bains M, Hancock RE, Strynadka NC, Nat Struct Mol Biol. 2007 Jan;14(1):85-7. Epub 2006 Dec 24. PMID:17187075

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