1mpa
From Proteopedia
(New page: 200px<br /> <applet load="1mpa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mpa, resolution 2.6Å" /> '''BACTERICIDAL ANTIBOD...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1MPA is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with CD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MPA OCA]]. | + | 1MPA is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with CD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: CDB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MPA OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: murine immunoglobulin igg2a kappa]] | [[Category: murine immunoglobulin igg2a kappa]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:36:24 2007'' |
Revision as of 12:31, 30 October 2007
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BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS
Overview
Class 1 outer membrane protein PorA of Neisseria meningitidis is a vaccine, candidate against bacterial meningitis. Antibodies against PorA are able, to induce complement-mediated bacterial killing and thereby play an, important role in protection against meningococcal disease. Bactericidal, antibodies are all directed against variable regions VR1 and VR2 of the, PorA sequence, corresponding to loops 1 and 4 of a two-dimensional, topology model of the porin with eight extracellular loops. We have, determined the crystal structure to 2.6 A resolution of the Fab fragment, of bactericidal antibody MN12H2 against meningococcal PorA in complex with, a linear fluorescein-conjugated peptide TKDTNNNL derived from the VR2, sequence of sero-subtype P1.7,16 (residues 180-187) from meningococcal, ... [(full description)]
About this Structure
1MPA is a [Protein complex] structure of sequences from [Mus musculus] with CD as [ligand]. Structure known Active Site: CDB. Full crystallographic information is available from [OCA].
Reference
Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide., van den Elsen JM, Herron JN, Hoogerhout P, Poolman JT, Boel E, Logtenberg T, Wilting J, Crommelin DJ, Kroon J, Gros P, Proteins. 1997 Sep;29(1):113-25. PMID:9294871
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