2of6
From Proteopedia
(New page: 200px<br /><applet load="2of6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2of6" /> '''Structure of immature West Nile virus'''<br ...) |
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| - | [[Image:2of6.gif|left|200px]]<br /><applet load="2of6" size=" | + | [[Image:2of6.gif|left|200px]]<br /><applet load="2of6" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''Structure of immature West Nile virus'''<br /> | '''Structure of immature West Nile virus'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OF6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http:// | + | 2OF6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:04:05 2008'' |
Revision as of 13:04, 23 January 2008
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Structure of immature West Nile virus
Overview
The structures of immature West Nile virus particles, propagated in the, presence of ammonium chloride to block virus maturation in the low pH, environment of the trans-Golgi network, were determined by cryoelectron, microscopy. The structures of these particles were similar to immature, West Nile virus particles found as a minor component of mature virus, samples ("naturally-occurring immature particles", NOIPs). The structure, of mature infectious flavivirus is radically different to that of the, immature particles. The similarity of the ammonium chloride-treated, particles and NOIPs suggests that either the NOIPs have not undergone any, conformational change during maturation or that the conformational change, is reversible. Comparison with immature dengue virus reconstructions, established the location of the N-linked glycosylation sites of these, viruses, verifying the interpretation of the reconstructions of the, immature flaviviruses.
About this Structure
2OF6 is a Single protein structure of sequence from West nile virus. Full crystallographic information is available from OCA.
Reference
Structure of Immature West Nile Virus., Zhang Y, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG, J Virol. 2007 Mar 21;. PMID:17376919
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