2uuf
From Proteopedia
(New page: 200px<br /> <applet load="2uuf" size="450" color="white" frame="true" align="right" spinBox="true" caption="2uuf, resolution 1.26Å" /> '''THROMBIN-HIRUGEN BI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2UUF is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUF OCA]]. | + | 2UUF is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Thrombin Thrombin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUF OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Thrombin]] | ||
[[Category: Ahmed, H.U.]] | [[Category: Ahmed, H.U.]] | ||
[[Category: Blakeley, M.P.]] | [[Category: Blakeley, M.P.]] | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:37:01 2007'' |
Revision as of 12:32, 30 October 2007
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THROMBIN-HIRUGEN BINARY COMPLEX AT 1.26A RESOLUTION
Overview
The protonation states of aspartic acids and glutamic acids as well as, histidine are investigated in four X-ray cases: Ni,Ca concanavalin A at, 0.94 A, a thrombin-hirugen binary complex at 1.26 A resolution and two, thrombin-hirugen-inhibitor ternary complexes at 1.32 and 1.39 A, resolution. The truncation of the Ni,Ca concanavalin A data at various, test resolutions between 0.94 and 1.50 A provided a test comparator for, the ;unknown' thrombin-hirugen carboxylate bond lengths. The protonation, states of aspartic acids and glutamic acids can be determined (on the, basis of convincing evidence) even to the modest resolution of 1.20 A as, exemplified by our X-ray crystal structure refinements of Ni and Mn, concanavalin A and also as indicated in the 1.26 A structure of thrombin, both of ... [(full description)]
About this Structure
2UUF is a [Protein complex] structure of sequences from [Homo sapiens] with NA and CA as [ligands]. Active as [Thrombin], with EC number [3.4.21.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The determination of protonation states in proteins., Ahmed HU, Blakeley MP, Cianci M, Cruickshank DW, Hubbard JA, Helliwell JR, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):906-22. Epub 2007, Jul 17. PMID:17642517
Page seeded by OCA on Tue Oct 30 14:37:01 2007
Categories: Homo sapiens | Protein complex | Thrombin | Ahmed, H.U. | Blakeley, M.P. | Cianci, M. | Cruickshank, D.W.J. | Helliwell, J.A.Hubbar J.R. | CA | NA | Acute phase | Blood clotting | Blood coagulation | Calcium | Cleavage on pair of basic residues | Disease mutation | Gamma-carboxyglutamic acid | Glycoprotein | High resolution | Hirugen | Hydrolase | Kringle | Polymorphism | Protease | Protease inhibitor | Secreted | Serine protease | Serine protease inhibitor | Serine proteinase | Sulfation | Zymogen
