2owl
From Proteopedia
(New page: 200px<br /><applet load="2owl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2owl, resolution 2.40Å" /> '''Crystal structure of...) |
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| - | [[Image:2owl.gif|left|200px]]<br /><applet load="2owl" size=" | + | [[Image:2owl.gif|left|200px]]<br /><applet load="2owl" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2owl, resolution 2.40Å" /> | caption="2owl, resolution 2.40Å" /> | ||
'''Crystal structure of E. coli RdgC'''<br /> | '''Crystal structure of E. coli RdgC'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OWL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2OWL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: replication]] | [[Category: replication]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:19:41 2008'' |
Revision as of 13:19, 23 January 2008
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Crystal structure of E. coli RdgC
Overview
The DNA-binding protein, RdgC, is associated with recombination and, replication fork repair in Escherichia coli and with the, virulence-associated, pilin antigenic variation mediated by RecA and other, recombination proteins in Neisseria species. We solved the structure of, the E. coli protein and refined it to 2.4A(.) RdgC crystallizes as a dimer, with a head-to-head, tail-to-tail organization forming a ring with a 30A, diameter hole at the center. The protein fold is unique and reminiscent of, a horseshoe with twin gates closing the open end. The central hole is, lined with positively charged residues and provides a highly plausible DNA, binding channel consistent with the nonspecific mode of binding detected, in vitro and with the ability of RdgC to modulate RecA function in vivo.
About this Structure
2OWL is a Single protein structure of sequence from Escherichia coli with as ligand. Full crystallographic information is available from OCA.
Reference
Ring Structure of the Escherichia coli DNA-binding Protein RdgC Associated with Recombination and Replication Fork Repair., Briggs GS, McEwan PA, Yu J, Moore T, Emsley J, Lloyd RG, J Biol Chem. 2007 Apr 27;282(17):12353-7. Epub 2007 Feb 16. PMID:17308310
Page seeded by OCA on Wed Jan 23 15:19:41 2008
Categories: Escherichia coli | Single protein | Briggs, G.S. | Emsley, J. | Lloyd, R.G. | McEwan, P.A. | Moore, T. | Yu, J. | CA | Reca | Recombination | Replication
