2oy6
From Proteopedia
(New page: 200px<br /><applet load="2oy6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oy6, resolution 3.0Å" /> '''Crystal structure of ...) |
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| - | [[Image:2oy6.jpg|left|200px]]<br /><applet load="2oy6" size=" | + | [[Image:2oy6.jpg|left|200px]]<br /><applet load="2oy6" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2oy6, resolution 3.0Å" /> | caption="2oy6, resolution 3.0Å" /> | ||
'''Crystal structure of Squid Mg.ADP myosin S1'''<br /> | '''Crystal structure of Squid Mg.ADP myosin S1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OY6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Loligo_plei Loligo plei] and [http://en.wikipedia.org/wiki/Todarodes_pacificus Todarodes pacificus] with MG and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2OY6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Loligo_plei Loligo plei] and [http://en.wikipedia.org/wiki/Todarodes_pacificus Todarodes pacificus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OY6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: squid]] | [[Category: squid]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:07:19 2008'' |
Revision as of 13:07, 23 January 2008
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Crystal structure of Squid Mg.ADP myosin S1
Overview
Unlike processive cellular motors such as myosin V, whose structure has, recently been determined in a "rigor-like" conformation, myosin II from, contracting muscle filaments necessarily spends most of its time detached, from actin. By using squid and sea scallop sources, however, we have now, obtained similar rigor-like atomic structures for muscle myosin heads, (S1). The significance of the hallmark closed actin-binding cleft in these, crystal structures is supported here by actin/S1-binding studies. These, structures reveal how different duty ratios, and hence cellular functions, of the myosin isoforms may be accounted for, in part, on the basis of, detailed differences in interdomain contacts. Moreover, the rigor-like, position of switch II turns out to be unique for myosin V. The overall, arrangements of subdomains in the motor are relatively conserved in each, of the known contractile states, and we explore qualitatively the, energetics of these states.
About this Structure
2OY6 is a Protein complex structure of sequences from Loligo plei and Todarodes pacificus with and as ligands. Full crystallographic information is available from OCA.
Reference
Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor., Yang Y, Gourinath S, Kovacs M, Nyitray L, Reutzel R, Himmel DM, O'neall-Hennessey E, Reshetnikova L, Szent-Gyorgyi AG, Brown JH, Cohen C, Structure. 2007 May;15(5):553-64. PMID:17502101
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