2p22
From Proteopedia
(New page: 200px<br /><applet load="2p22" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p22, resolution 2.70Å" /> '''Structure of the Yea...) |
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| - | [[Image:2p22.jpg|left|200px]]<br /><applet load="2p22" size=" | + | [[Image:2p22.jpg|left|200px]]<br /><applet load="2p22" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2p22, resolution 2.70Å" /> | caption="2p22, resolution 2.70Å" /> | ||
'''Structure of the Yeast ESCRT-I Heterotetramer Core'''<br /> | '''Structure of the Yeast ESCRT-I Heterotetramer Core'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2P22 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2P22 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P22 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: vps37]] | [[Category: vps37]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:01:30 2008'' |
Revision as of 13:01, 23 January 2008
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Structure of the Yeast ESCRT-I Heterotetramer Core
Overview
The endosomal sorting complex required for transport-I (ESCRT-I) complex, which is conserved from yeast to humans, directs the lysosomal degradation, of ubiquitinated transmembrane proteins and the budding of the HIV virus., Yeast ESCRT-I contains four subunits, Vps23, Vps28, Vps37, and Mvb12. The, crystal structure of the heterotetrameric ESCRT-I complex reveals a highly, asymmetric complex of 1:1:1:1 subunit stoichiometry. The core complex is, nearly 18 nm long and consists of a headpiece attached to a 13 nm stalk., The stalk is important for cargo sorting by ESCRT-I and is proposed to, serve as a spacer regulating the correct disposition of cargo and other, ESCRT components. Hydrodynamic constraints and crystallographic structures, were used to generate a model of intact ESCRT-I in solution. The results, show how ESCRT-I uses a combination of a rigid stalk and flexible tethers, to interact with lipids, cargo, and other ESCRT complexes over a span of, approximately 25 nm.
About this Structure
2P22 is a Protein complex structure of sequences from Saccharomyces cerevisiae with as ligand. Full crystallographic information is available from OCA.
Reference
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer., Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH, Cell. 2007 May 4;129(3):485-98. Epub 2007 Apr 19. PMID:17442384
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