2pdz
From Proteopedia
(New page: 200px<br /><applet load="2pdz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pdz" /> '''SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOM...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2pdz.jpg|left|200px]]<br /><applet load="2pdz" size=" | + | [[Image:2pdz.jpg|left|200px]]<br /><applet load="2pdz" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2pdz" /> | caption="2pdz" /> | ||
'''SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES'''<br /> | '''SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Syntrophins are modular proteins belonging to the dystrophin associated | + | Syntrophins are modular proteins belonging to the dystrophin associated glycoprotein complex and are thought to be involved in the regulation of the muscular system. Screening of peptide libraries revealed selectivity of the synotrophin PDZ domain toward the motif R/K/Q-E-S/T-X-V-COO- found to be highly conserved in the alpha-subunit C-terminus of vertebrate voltage gated sodium channels (VGSCs). The solution structure of the domain in complex with the peptide G-V-K-E-S-L-V shows specific interactions between the conserved residues in the peptide and syntrophin-characteristic residues in the domain. We propose that syntrophins localize VGSCs to the dystrophin network through its PDZ domain. |
==About this Structure== | ==About this Structure== | ||
| - | 2PDZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 2PDZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PDZ OCA]. |
==Reference== | ==Reference== | ||
| Line 26: | Line 26: | ||
[[Category: voltage-gated sodium channel]] | [[Category: voltage-gated sodium channel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:28:27 2008'' |
Revision as of 16:28, 21 February 2008
|
SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES
Overview
Syntrophins are modular proteins belonging to the dystrophin associated glycoprotein complex and are thought to be involved in the regulation of the muscular system. Screening of peptide libraries revealed selectivity of the synotrophin PDZ domain toward the motif R/K/Q-E-S/T-X-V-COO- found to be highly conserved in the alpha-subunit C-terminus of vertebrate voltage gated sodium channels (VGSCs). The solution structure of the domain in complex with the peptide G-V-K-E-S-L-V shows specific interactions between the conserved residues in the peptide and syntrophin-characteristic residues in the domain. We propose that syntrophins localize VGSCs to the dystrophin network through its PDZ domain.
About this Structure
2PDZ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels., Schultz J, Hoffmuller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H, Nat Struct Biol. 1998 Jan;5(1):19-24. PMID:9437424
Page seeded by OCA on Thu Feb 21 18:28:27 2008
