2gmv
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2gmv.png|left|200px]] | [[Image:2gmv.png|left|200px]] | ||
| Line 18: | Line 17: | ||
--> | --> | ||
{{ABSTRACT_PUBMED_17532214}} | {{ABSTRACT_PUBMED_17532214}} | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: Hypoglycemia due to PCK1 deficiency (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=261680 261680]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2gmv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GMV OCA]. | |
==Reference== | ==Reference== | ||
| Line 33: | Line 29: | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Xanthine]] | [[Category: Xanthine]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:17:41 2009'' | ||
Revision as of 00:18, 15 March 2011
PEPCK complex with a GTP-competitive inhibitor
Template:ABSTRACT PUBMED 17532214
About this Structure
2gmv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Pietranico SL, Foley LH, Huby N, Yun W, Dunten P, Vermeulen J, Wang P, Toth K, Ramsey G, Gubler ML, Wertheimer SJ. C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3835-9. Epub 2007 May 22. PMID:17532214 doi:http://dx.doi.org/10.1016/j.bmcl.2007.05.013
- Foley LH, Wang P, Dunten P, Ramsey G, Gubler ML, Wertheimer SJ. X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3871-4. PMID:14552798
- Dunten P, Belunis C, Crowther R, Hollfelder K, Kammlott U, Levin W, Michel H, Ramsey GB, Swain A, Weber D, Wertheimer SJ. Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J Mol Biol. 2002 Feb 15;316(2):257-64. PMID:11851336 doi:http://dx.doi.org/10.1006/jmbi.2001.5364
