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User:Amy Rumora/Sandbox 1
From Proteopedia
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| - | + | BACE1 (β-Secretase) is a class I transmembrane aspartyl protease that cleaves the β-amyloid Precursor Protein (APP) in a [[rate limiting step]] that contributes to the accumulation of (β-amyloid plaques) in (Alzheimer’s disease (AD)). A subsequent cleavage by (γ-secretase) generates a 40 or 42 amino acid (β-amyloid peptide). These Aβ plaques may have deleterious effect on neuronal function and contribute in pathologies of (AD). Alike other class I aspartyl proteases BACE1 contains a catalytic dyad in the cleft of the bilobal structure. On the other hand, BACE1 is unique in it’s ability to <scene name='User:Amy_Rumora/Sandbox_1/Practice1/1'>pH7</scene> | |
<scene name='User:Amy_Rumora/Sandbox_1/Practice2/1'>pH4</scene> | <scene name='User:Amy_Rumora/Sandbox_1/Practice2/1'>pH4</scene> | ||
Revision as of 23:03, 21 April 2009
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BACE1 (β-Secretase) is a class I transmembrane aspartyl protease that cleaves the β-amyloid Precursor Protein (APP) in a rate limiting step that contributes to the accumulation of (β-amyloid plaques) in (Alzheimer’s disease (AD)). A subsequent cleavage by (γ-secretase) generates a 40 or 42 amino acid (β-amyloid peptide). These Aβ plaques may have deleterious effect on neuronal function and contribute in pathologies of (AD). Alike other class I aspartyl proteases BACE1 contains a catalytic dyad in the cleft of the bilobal structure. On the other hand, BACE1 is unique in it’s ability to
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