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3cwj

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Revision as of 07:54, 6 May 2009

Image:3cwj.png

Template:STRUCTURE 3cwj

Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor

Template:ABSTRACT PUBMED 18662878

About this Structure

3CWJ is a 2 chains structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Ellis DA, Blazel JK, Webber SE, Tran CV, Dragovich PS, Sun Z, Ruebsam F, McGuire HM, Xiang AX, Zhao J, Li LS, Zhou Y, Han Q, Kissinger CR, Showalter RE, Lardy M, Shah AM, Tsan M, Patel R, LeBrun LA, Kamran R, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L. 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyr idazin-3-ones as potent inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4628-32. Epub 2008 Jul 10. PMID:18662878 doi:10.1016/j.bmcl.2008.07.014

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