Rebecca Martin/Sandbox1
From Proteopedia
(Difference between revisions)
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:: Model of human IgA1 determined by solution scattering, curve-fitting, and homology modeling [[1iga]] | :: Model of human IgA1 determined by solution scattering, curve-fitting, and homology modeling [[1iga]] | ||
:: Model of human IgA2 determined by solution scattering, curve fitting and homology modelling [[1r70]] | :: Model of human IgA2 determined by solution scattering, curve fitting and homology modelling [[1r70]] | ||
| - | * Fab | + | * Fab and Fc Fragments |
:: Refined crystal structure of the galactan-binding immunoglobulin fab j539 at 1.95-angstroms resolution [[2fbj]] | :: Refined crystal structure of the galactan-binding immunoglobulin fab j539 at 1.95-angstroms resolution [[2fbj]] | ||
:: Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 2.7 angstroms [[1mcp]] | :: Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 2.7 angstroms [[1mcp]] | ||
| - | * Fc Fragment | ||
:: Crystal structure of human FcaRI bound to IgA1-Fc [[1ow0]] | :: Crystal structure of human FcaRI bound to IgA1-Fc [[1ow0]] | ||
| - | * Dimeric | + | * Dimeric and Secretory |
:: Solution structure of human dimeric immunoglobulin A [[2qtj]] | :: Solution structure of human dimeric immunoglobulin A [[2qtj]] | ||
| - | * Secretory | ||
:: Solution structure of human secretory IgA1 [[3chn]] | :: Solution structure of human secretory IgA1 [[3chn]] | ||
:: Solution Structure of Human SIgA2 [[3cm9]] | :: Solution Structure of Human SIgA2 [[3cm9]] | ||
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* Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 [[2qej]] | * Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 [[2qej]] | ||
| - | === | + | === Other Isotypes (for comparison) === |
* IgM: Solution structure of human Immunoglobulin M [[2rcj]] | * IgM: Solution structure of human Immunoglobulin M [[2rcj]] | ||
* IgG: | * IgG: | ||
Revision as of 14:26, 22 April 2009
Contents |
Introduction
IgA1
General Structure
- Antibody Structure
- Dimeric Structure
- Secretory Component
IgA1 and IgA2
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Secretory Component and Polyimmunoglobulin receptor
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Insights into Function
Evolution
Implications in Science and Medicine
Limitations of the Current Studies
- Because of the nature of the IgA molecule, crystalizing this structure was not possible. Therefore, many of these structures are based on models and not actual crystal structures. Because ...., the models were depositable in the PDB. I tried to include other crystallographic data when available, supporting the proposed models- as the authors did in the original papers.
Questions for the Future
- Because of the limitating resolution of these models, many details concerning the binding residues and residue interactions are left unknown. Crystallographic structure will yield further insights into the structure of IgA, the interactions between IgA and other molecules, and ....
Links
IgA
- Monomeric
- Fab and Fc Fragments
- Dimeric and Secretory
Receptors
- Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 1XED
- Crystal structure of human FcaRI 10vz
- Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 2qej
Other Isotypes (for comparison)
- IgM: Solution structure of human Immunoglobulin M 2rcj
- IgG:
- IgD:
- IgE:
