2wf4

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'''Unreleased structure'''
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{{Seed}}
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[[Image:2wf4.jpg|left|200px]]
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The entry 2wf4 is ON HOLD until Paper Publication
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{{STRUCTURE_2wf4| PDB=2wf4 | SCENE= }}
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Authors: Charrier, N., Clarke, B., Cutler, L., Demont, E., Dingwall, C., Dunsdon, R., Hawkins, J., Howes, C., Hubbard, J., Hussain, I., Maile, G., Matico, R., Mosley, J., Naylor, A., O'Brien, A., Redshaw, S., Rowland, P., Soleil, V., Smith, K.J., Sweitzer, S., Theobald, P., Vesey, D., Walter, D.S., Wayne, G.
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===HUMAN BACE-1 IN COMPLEX WITH 6-ETHYL-1-METHYL-N-((1S)-2-OXO-1-(PHENYLMETHYL)-3-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PROPYL)-1,3,4,6-TETRAHYDRO(1,2)THIAZEPINO(5,4,3-CD)INDOLE-8-CARBOXAMIDE 2,2-DIOXIDE===
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Description: Human BACE-1 in complex with 6-ethyl-1-methyl-N-((1S)-2-oxo-1-( phenylmethyl)-3-(tetrahydro-2H-pyran-4-ylamino)propyl)-1,3,4,6-tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8-carboxamide 2,2-dioxide
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 08:30:18 2009''
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The line below this paragraph, {{ABSTRACT_PUBMED_19406640}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 19406640 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19406640}}
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==About this Structure==
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2WF4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF4 OCA].
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==Reference==
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<ref group="xtra">PMID:19406640</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Brien, A O.]]
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[[Category: Charrier, N.]]
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[[Category: Clarke, B.]]
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[[Category: Cutler, L.]]
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[[Category: Demont, E.]]
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[[Category: Dingwall, C.]]
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[[Category: Dunsdon, R.]]
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[[Category: Hawkins, J.]]
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[[Category: Howes, C.]]
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[[Category: Hubbard, J.]]
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[[Category: Hussain, I.]]
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[[Category: Maile, G.]]
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[[Category: Matico, R.]]
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[[Category: Mosley, J.]]
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[[Category: Naylor, A.]]
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[[Category: Redshaw, S.]]
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[[Category: Rowland, P.]]
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[[Category: Smith, K J.]]
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[[Category: Soleil, V.]]
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[[Category: Sweitzer, S.]]
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[[Category: Theobald, P.]]
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[[Category: Vesey, D.]]
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[[Category: Walter, D S.]]
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[[Category: Wayne, G.]]
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[[Category: Alternative splicing]]
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[[Category: Asp-2]]
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[[Category: Aspartyl protease]]
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[[Category: Bace-1]]
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[[Category: Beta-secretase]]
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[[Category: Beta-site app cleaving enzyme]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Memapsin-2]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 09:58:36 2009''

Revision as of 06:58, 13 May 2009

Image:2wf4.jpg

Template:STRUCTURE 2wf4

HUMAN BACE-1 IN COMPLEX WITH 6-ETHYL-1-METHYL-N-((1S)-2-OXO-1-(PHENYLMETHYL)-3-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PROPYL)-1,3,4,6-TETRAHYDRO(1,2)THIAZEPINO(5,4,3-CD)INDOLE-8-CARBOXAMIDE 2,2-DIOXIDE

Template:ABSTRACT PUBMED 19406640

About this Structure

2WF4 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Charrier N, Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hubbard J, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G. Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3674-8. Epub 2009 Apr 5. PMID:19406640 doi:10.1016/j.bmcl.2009.03.149

Page seeded by OCA on Wed May 13 09:58:36 2009

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