2v9v
From Proteopedia
(New page: 200px<br /> <applet load="2v9v" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v9v, resolution 1.10Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2V9V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]] with CL and NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V9V OCA]]. | + | 2V9V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]] with CL and NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V9V OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: winged-helix domain]] | [[Category: winged-helix domain]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:51:04 2007'' |
Revision as of 15:46, 30 October 2007
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CRYSTAL STRUCTURE OF MOORELLA THERMOACETICA SELB(377-511)
Overview
The crystal structure of the first two winged-helix motifs of translation, elongation factor SelB from Moorella thermoacetica has been determined at, 1.1 A resolution. Compared with the previous structure of the two domains, in conjunction with winged-helix modules 3 and 4, the first winged-helix, domain underwent a substantial conformational change during which the, alpha-helical and beta-sheet portions of the element opened up like a, shell. This conformational rearrangement was elicited by a change in the, orientation of Trp396, leading to the disclosure of a bona fide, ligand-binding site in the direct vicinity of Trp396. Additionally, the, C-terminal tail of the second domain followed a different path compared, with the previous structure. It is conceivable that these conformational, ... [(full description)]
About this Structure
2V9V is a [Single protein] structure of sequence from [Moorella thermoacetica] with CL and NA as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Conformational switches in winged-helix domains 1 and 2 of bacterial translation elongation factor SelB., Ganichkin O, Wahl MC, Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1075-81. Epub 2007, Sep 19. PMID:17881825
Page seeded by OCA on Tue Oct 30 17:51:04 2007
Categories: Moorella thermoacetica | Single protein | Ganichkin, O. | Wahl, M.C. | CL | NA | Cytoplasm | Gtp-binding | Nucleotide-binding | Protein biosynthesis | Protein conformational change | Protein dynamics | Selenocysteine | Selenoprotein biosynthesis | Transcription elongation factor selb | Winged-helix domain
