2v1u
From Proteopedia
(New page: 200px<br /> <applet load="2v1u" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v1u, resolution 3.10Å" /> '''STRUCTURE OF THE AE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2V1U is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]] with MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V1U OCA]]. | + | 2V1U is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]] with MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V1U OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: replication]] | [[Category: replication]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:51:21 2007'' |
Revision as of 15:46, 30 October 2007
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STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA
Overview
DNA replication in archaea and in eukaryotes share many similarities. We, report the structure of an archaeal origin recognition complex protein, ORC1, bound to an origin recognition box, a DNA sequence that is found in, multiple copies at replication origins. DNA binding is mediated, principally by a C-terminal winged helix domain that inserts deeply into, the major and minor grooves, widening them both. However, additional DNA, contacts are made with the N-terminal AAA+ domain, which inserts into the, minor groove at a characteristic G-rich sequence, inducing a 35 degrees, bend in the duplex and providing directionality to the binding site. Both, contact regions also induce substantial unwinding of the DNA. The, structure provides insight into the initial step in assembly of a, ... [(full description)]
About this Structure
2V1U is a [Protein complex] structure of sequences from [Aeropyrum pernix] with MG and ADP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural basis of DNA replication origin recognition by an ORC protein., Gaudier M, Schuwirth BS, Westcott SL, Wigley DB, Science. 2007 Aug 31;317(5842):1213-6. PMID:17761880
Page seeded by OCA on Tue Oct 30 17:51:21 2007
