2j4a
From Proteopedia
(New page: 200px<br /> <applet load="2j4a" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j4a, resolution 2.2Å" /> '''HUMAN THYROID HORMON...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J4A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with OEF as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J4A OCA]]. | + | 2J4A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with OEF as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J4A OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:51:50 2007'' |
Revision as of 15:47, 30 October 2007
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HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084
Overview
A new high-affinity thyroid hormone antagonist 6 with druglike properties, was designed and synthesized. The compound behaved as an antagonist in a, cell transactivation assay, and in a first in vivo experiment in rats.
About this Structure
2J4A is a [Single protein] structure of sequence from [Homo sapiens] with OEF as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor., Koehler K, Gordon S, Brandt P, Carlsson B, Backsbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Farnegardh M, Rehnmark S, Malm J, J Med Chem. 2006 Nov 16;49(23):6635-7. PMID:17154490
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