2v84
From Proteopedia
(New page: 200px<br /> <applet load="2v84" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v84, resolution 1.78Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2V84 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]] with CL and MES as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V84 OCA]]. | + | 2V84 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]] with CL and MES as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V84 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: treponema pallidum]] | [[Category: treponema pallidum]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:52:10 2007'' |
Revision as of 15:47, 30 October 2007
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CRYSTAL STRUCTURE OF THE TP0655 (TPPOTD) LIPOPROTEIN OF TREPONEMA PALLIDUM
Overview
Tp0655 of Treponema pallidum, the causative agent of syphilis, is, predicted to be a 40 kDa membrane lipoprotein. Previous sequence analysis, of Tp0655 noted its homology to polyamine-binding proteins of the, bacterial PotD family, which serve as periplasmic ligand-binding proteins, of ATP-binding-cassette (ABC) transport systems. Here, the 1.8 A crystal, structure of Tp0655 demonstrated structural homology to Escherichia coli, PotD and PotF. The latter two proteins preferentially bind spermidine and, putrescine, respectively. All of these proteins contain two domains that, sandwich the ligand between them. The ligand-binding site of Tp0655 can be, occupied by 2-(N-morpholino)ethanesulfanoic acid, a component of the, crystallization medium. To discern the polyamine binding preferences of, ... [(full description)]
About this Structure
2V84 is a [Single protein] structure of sequence from [Treponema pallidum] with CL and MES as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor., Machius M, Brautigam CA, Tomchick DR, Ward P, Otwinowski Z, Blevins JS, Deka RK, Norgard MV, J Mol Biol. 2007 Aug 21;. PMID:17868688
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