3cwj
From Proteopedia
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===Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor=== | ===Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3cwj]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWJ OCA]. | |
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| + | ==See Also== | ||
| + | *[[RNA polymerase|RNA polymerase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018662878</ref><references group="xtra"/> |
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
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[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
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Revision as of 21:53, 26 July 2012
Contents |
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Template:ABSTRACT PUBMED 18662878
About this Structure
3cwj is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Ellis DA, Blazel JK, Webber SE, Tran CV, Dragovich PS, Sun Z, Ruebsam F, McGuire HM, Xiang AX, Zhao J, Li LS, Zhou Y, Han Q, Kissinger CR, Showalter RE, Lardy M, Shah AM, Tsan M, Patel R, LeBrun LA, Kamran R, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L. 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyr idazin-3-ones as potent inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4628-32. Epub 2008 Jul 10. PMID:18662878 doi:10.1016/j.bmcl.2008.07.014
