1e4f
From Proteopedia
(New page: 200px<br /><applet load="1e4f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e4f, resolution 1.9Å" /> '''FTSA (APO FORM) FROM ...) |
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| - | [[Image:1e4f.gif|left|200px]]<br /><applet load="1e4f" size=" | + | [[Image:1e4f.gif|left|200px]]<br /><applet load="1e4f" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1e4f, resolution 1.9Å" /> | caption="1e4f, resolution 1.9Å" /> | ||
'''FTSA (APO FORM) FROM THERMOTOGA MARITIMA'''<br /> | '''FTSA (APO FORM) FROM THERMOTOGA MARITIMA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Bacterial cell division requires formation of a septal ring. A key step in | + | Bacterial cell division requires formation of a septal ring. A key step in septum formation is polymerization of FtsZ. FtsA directly interacts with FtsZ and probably targets other proteins to the septum. We have solved the crystal structure of FtsA from Thermotoga maritima in the apo and ATP-bound form. FtsA consists of two domains with the nucleotide-binding site in the interdomain cleft. Both domains have a common core that is also found in the actin family of proteins. Structurally, FtsA is most homologous to actin and heat-shock cognate protein (Hsc70). An important difference between FtsA and the actin family of proteins is the insertion of a subdomain in FtsA. Movement of this subdomain partially encloses a groove, which could bind the C-terminus of FtsZ. FtsZ is the bacterial homologue of tubulin, and the FtsZ ring is functionally similar to the contractile ring in dividing eukaryotic cells. Elucidation of the crystal structure of FtsA shows that another bacterial protein involved in cytokinesis is structurally related to a eukaryotic cytoskeletal protein involved in cytokinesis. |
==About this Structure== | ==About this Structure== | ||
| - | 1E4F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http:// | + | 1E4F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E4F OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
| - | [[Category: Ent, F | + | [[Category: Ent, F Van Den.]] |
[[Category: Lowe, J.]] | [[Category: Lowe, J.]] | ||
[[Category: actin family]] | [[Category: actin family]] | ||
[[Category: bacterial cell division]] | [[Category: bacterial cell division]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:23:44 2008'' |
Revision as of 10:23, 21 February 2008
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FTSA (APO FORM) FROM THERMOTOGA MARITIMA
Overview
Bacterial cell division requires formation of a septal ring. A key step in septum formation is polymerization of FtsZ. FtsA directly interacts with FtsZ and probably targets other proteins to the septum. We have solved the crystal structure of FtsA from Thermotoga maritima in the apo and ATP-bound form. FtsA consists of two domains with the nucleotide-binding site in the interdomain cleft. Both domains have a common core that is also found in the actin family of proteins. Structurally, FtsA is most homologous to actin and heat-shock cognate protein (Hsc70). An important difference between FtsA and the actin family of proteins is the insertion of a subdomain in FtsA. Movement of this subdomain partially encloses a groove, which could bind the C-terminus of FtsZ. FtsZ is the bacterial homologue of tubulin, and the FtsZ ring is functionally similar to the contractile ring in dividing eukaryotic cells. Elucidation of the crystal structure of FtsA shows that another bacterial protein involved in cytokinesis is structurally related to a eukaryotic cytoskeletal protein involved in cytokinesis.
About this Structure
1E4F is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Crystal structure of the cell division protein FtsA from Thermotoga maritima., van den Ent F, Lowe J, EMBO J. 2000 Oct 16;19(20):5300-7. PMID:11032797
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