X-ray crystallography
From Proteopedia
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| - | About 85% of the models (entries) in the [[Protein Data Bank|World Wide Protein Data Bank]] were determined by X-ray crystallography. Protein crystallography remains very difficult, despite many recent advances. For every protein sequence targeted for X-ray crystallography, about one in twenty is solved | + | About 85% of the models (entries) in the [[Protein Data Bank|World Wide Protein Data Bank]] were determined by X-ray crystallography. (Most of the remaining 15% were determined by [[NMR|solution nuclear magnetic resonance]]. Protein crystallography remains very difficult, despite many recent advances. For every new protein sequence targeted for X-ray crystallography, about one in twenty is solved<ref>[http://proteinexplorer.org/gpsi/xrc_succ.htm Success Rates in Protein Crystallography]</ref><ref>[http://proteinexplorer.org/gpsi/xsuccess.htm Structural Genomics Progress Chart]</ref>. Publication of solved structures involves depositing an [[Atomic coordinate file]] in the [Protein Data Bank|World Wide Protein Data Bank]]. |
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| + | ==See Also== | ||
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| + | *[[Resolution]] | ||
| + | *[[R value]] | ||
| + | *[[Free R]] | ||
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| + | *[[Highest impact structures]] of all time. | ||
==Notes & References== | ==Notes & References== | ||
<references /> | <references /> | ||
Revision as of 20:55, 18 May 2009
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| Flow chart showing the major steps in X-ray protein crystallography. (Image from Wikimedia courtesy Thomas Splettstoesser. |
About 85% of the models (entries) in the World Wide Protein Data Bank were determined by X-ray crystallography. (Most of the remaining 15% were determined by solution nuclear magnetic resonance. Protein crystallography remains very difficult, despite many recent advances. For every new protein sequence targeted for X-ray crystallography, about one in twenty is solved[1][2]. Publication of solved structures involves depositing an Atomic coordinate file in the [Protein Data Bank|World Wide Protein Data Bank]].
See Also
- Highest impact structures of all time.
