159d

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(New page: 200px<br /><applet load="159d" size="450" color="white" frame="true" align="right" spinBox="true" caption="159d, resolution 1.800&Aring;" /> '''SIDE BY SIDE BINDIN...)
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[[Image:159d.gif|left|200px]]<br /><applet load="159d" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:159d.gif|left|200px]]<br /><applet load="159d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="159d, resolution 1.800&Aring;" />
caption="159d, resolution 1.800&Aring;" />
'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''<br />
'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''<br />
==Overview==
==Overview==
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Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between, distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two, distamycin A molecules are bound side by side with dyad symmetry in an, antiparallel orientation in the expanded minor groove. The amides of each, drug molecule are hydrogen bonded to the minor groove base atoms of only, one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the, helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a, dinucleotide repeat.
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Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two distamycin A molecules are bound side by side with dyad symmetry in an antiparallel orientation in the expanded minor groove. The amides of each drug molecule are hydrogen bonded to the minor groove base atoms of only one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a dinucleotide repeat.
==About this Structure==
==About this Structure==
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159D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DMY and MG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=159D OCA].
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159D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DMY:'>DMY</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=159D OCA].
==Reference==
==Reference==
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[[Category: Chen, X.]]
[[Category: Chen, X.]]
[[Category: Ramakrishnan, B.]]
[[Category: Ramakrishnan, B.]]
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[[Category: Rao, S.T.]]
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[[Category: Rao, S T.]]
[[Category: Sundaralingam, M.]]
[[Category: Sundaralingam, M.]]
[[Category: DMY]]
[[Category: DMY]]
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[[Category: modified]]
[[Category: modified]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:00:39 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:38:30 2008''

Revision as of 09:38, 21 February 2008

Image:159d.gif

159d, resolution 1.800Å

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SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX

Overview

Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two distamycin A molecules are bound side by side with dyad symmetry in an antiparallel orientation in the expanded minor groove. The amides of each drug molecule are hydrogen bonded to the minor groove base atoms of only one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a dinucleotide repeat.

About this Structure

159D is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.

Reference

Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:7656035

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