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176d
From Proteopedia
(New page: 200px<br /><applet load="176d" size="450" color="white" frame="true" align="right" spinBox="true" caption="176d" /> '''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ...) |
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| - | [[Image:176d.jpg|left|200px]]<br /><applet load="176d" size=" | + | [[Image:176d.jpg|left|200px]]<br /><applet load="176d" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="176d" /> | caption="176d" /> | ||
'''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA'''<br /> | '''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Peptide nucleic acids (PNA) incorporating nucleic acid bases into an | + | Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents. |
==About this Structure== | ==About this Structure== | ||
| - | 176D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 176D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA]. |
==Reference== | ==Reference== | ||
NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7519361 7519361] | NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7519361 7519361] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Brown, S | + | [[Category: Brown, S C.]] |
| - | [[Category: Veal, J | + | [[Category: Veal, J M.]] |
[[Category: double helix]] | [[Category: double helix]] | ||
[[Category: nmr]] | [[Category: nmr]] | ||
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[[Category: rna]] | [[Category: rna]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:38:55 2008'' |
Revision as of 09:39, 21 February 2008
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NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA
Overview
Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
About this Structure
176D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:7519361
Page seeded by OCA on Thu Feb 21 11:38:55 2008
Categories: Protein complex | Brown, S C. | Veal, J M. | Double helix | Nmr | Pna | Rna
